| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent proline transporter |
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| Ligand | BDBM50052643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1456629 (CHEMBL3370229) |
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| IC50 | 1020±n/a nM |
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| Citation |  Zipp, GG; Barbosa, J; Green, MA; Terranova, KM; Fink, C; Yu, XC; Nouraldeen, A; Wilson, A; Savelieva, K; Lanthorn, TH; David Kimball, S Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett24:3886-90 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent proline transporter |
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| Name: | Sodium-dependent proline transporter |
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| Synonyms: | PROT | SC6A7_HUMAN | SLC6A7 | Sodium-dependent proline transporter | Solute carrier family 6 member 7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70910.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109456 |
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| Residue: | 636 |
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| Sequence: | MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV
WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA
AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP
LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG
KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG
VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA
KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR
PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ
RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI
LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS
PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM
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| BDBM50052643 |
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| n/a |
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| Name | BDBM50052643 |
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| Synonyms: | CHEMBL3318568 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N4O2 |
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| Mol. Mass. | 388.4623 |
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| SMILES | O=C(N1CCN(CC1)c1ncccn1)c1ccc(OCCc2ccccc2)cc1 |
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| Structure | 
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