Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50054691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1453126 (CHEMBL3364424) |
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IC50 | >20000±n/a nM |
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Citation | Li, J; Kennedy, LJ; Wang, H; Li, JJ; Walker, SJ; Hong, Z; O'Connor, SP; Nayeem, A; Camac, DM; Morin, PE; Sheriff, S; Wang, M; Harper, T; Golla, R; Seethala, R; Harrity, T; Ponticiello, RP; Morgan, NN; Taylor, JR; Zebo, R; Gordon, DA; Robl, JA Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1). ACS Med Chem Lett5:803-8 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50054691 |
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n/a |
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Name | BDBM50054691 |
Synonyms: | CHEMBL3318978 |
Type | Small organic molecule |
Emp. Form. | C18H16ClN3 |
Mol. Mass. | 309.793 |
SMILES | Clc1ccc(cc1)C1(CC1)c1nnc2c(cccn12)C1CC1 |
Structure |
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