| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50056450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1452286 (CHEMBL3366540) |
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| EC50 | >50000±n/a nM |
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| Citation |  Santella, JB; Gardner, DS; Duncia, JV; Wu, H; Dhar, M; Cavallaro, C; Tebben, AJ; Carter, PH; Barrish, JC; Yarde, M; Briceno, SW; Cvijic, ME; Grafstrom, RR; Liu, R; Patel, SR; Watson, AJ; Yang, G; Rose, AV; Vickery, RD; Caceres-Cortes, J; Caporuscio, C; Camac, DM; Khan, JA; An, Y; Foster, WR; Davies, P; Hynes, J Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem57:7550-64 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
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| Type: | Nuclear receptor |
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| Mol. Mass.: | 49774.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75469 |
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| Residue: | 434 |
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| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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| BDBM50056450 |
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| n/a |
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| Name | BDBM50056450 |
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| Synonyms: | CHEMBL3334726 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H36ClN3O4 |
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| Mol. Mass. | 466.013 |
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| SMILES | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 |r| |
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| Structure | 
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