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TargetMannose-6-phosphate isomerase
LigandBDBM61910
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1448919 (CHEMBL3375686)
IC50 1300±n/a nM
Citation Bravo, YTeriete, PDhanya, RPDahl, RLee, PSKiffer-Moreira, TGanji, SRSergienko, ESmith, LHFarquharson, CMillán, JLCosford, ND Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorg Med Chem Lett24:4308-11 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mannose-6-phosphate isomerase
Name:Mannose-6-phosphate isomerase
Synonyms:MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:PROTEIN
Mol. Mass.:46651.35
Organism:Homo sapiens (Human)
Description:ChEMBL_1448919
Residue:423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM61910
n/a
NameBDBM61910
Synonyms:6-fluoranyl-2-phenyl-1,2-benzothiazol-3-one | 6-fluoro-2-phenyl-1,2-benzothiazol-3-one | KUC103671N | cid_1510378
TypeSmall organic molecule
Emp. Form.C13H8FNOS
Mol. Mass.245.272
SMILESFc1ccc2c(c1)sn(-c1ccccc1)c2=O
Structure
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