| Reaction Details |
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 | Report a problem with these data |
| Target | Gastricsin |
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| Ligand | BDBM50065660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1464650 (CHEMBL3406671) |
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| IC50 | >30000±n/a nM |
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| Citation |  Sellner, H; Cottens, S; Cumin, F; Ehrhardt, C; Kosaka, T; Lorthiois, E; Ostermann, N; Webb, RL; Rigel, DF; Wagner, T; Maibaum, J trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker. Bioorg Med Chem Lett25:1787-91 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastricsin |
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| Name: | Gastricsin |
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| Synonyms: | Gastricsin | PEPC_HUMAN | PGC | Pepsinogen C |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42409.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1452207 |
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| Residue: | 388 |
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| Sequence: | MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLS
VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSES
STYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIM
GLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIY
WAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQE
DEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPL
WILGDVFLRSYYSVYDLGNNRVGFATAA
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| BDBM50065660 |
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| n/a |
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| Name | BDBM50065660 |
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| Synonyms: | CHEMBL3403995 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N3O6 |
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| Mol. Mass. | 513.6258 |
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| SMILES | COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1OC(=O)NCc1ccccc1)C(C)C |r| |
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| Structure | 
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