Reaction Details |
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Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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Ligand | BDBM16661 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1464323 (CHEMBL3404590) |
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Ki | 1390±n/a nM |
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Citation | Al-Rashida, M; Ejaz, SA; Ali, S; Shaukat, A; Hamayoun, M; Ahmed, M; Iqbal, J Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies. Bioorg Med Chem23:2435-44 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alkaline phosphatase, tissue-nonspecific isozyme |
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Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
Synonyms: | ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP) |
Type: | Protein |
Mol. Mass.: | 57195.60 |
Organism: | Bos taurus (Cattle) |
Description: | P09487 |
Residue: | 524 |
Sequence: | MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
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BDBM16661 |
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n/a |
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Name | BDBM16661 |
Synonyms: | 1-N-(4-fluorobenzene)benzene-1,4-disulfonamide | aromatic sulfonamide compound 26 |
Type | Small organic molecule |
Emp. Form. | C12H11FN2O4S2 |
Mol. Mass. | 330.355 |
SMILES | NS(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1 |
Structure |
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