| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50068347 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1466467 (CHEMBL3406577) |
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| IC50 | 26800±n/a nM |
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| Citation |  Wieckowska, A; Wieckowski, K; Bajda, M; Brus, B; Salat, K; Czerwinska, P; Gobec, S; Filipek, B; Malawska, B Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors withß-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorg Med Chem23:2445-57 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65643.35 |
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| Organism: | Equus caballus (Horse) |
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| Description: | P81908 |
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| Residue: | 574 |
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| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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| BDBM50068347 |
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| n/a |
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| Name | BDBM50068347 |
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| Synonyms: | CHEMBL3402300 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N3O3 |
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| Mol. Mass. | 407.5054 |
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| SMILES | COc1ccc(CN2CCC(CC2)NCCCN2C(=O)c3ccccc3C2=O)cc1 |
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| Structure | 
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