Reaction Details | |||
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Target | E3 ubiquitin-protein ligase Mdm2 | ||
Ligand | BDBM50069781 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1469499 (CHEMBL3412296) | ||
IC50 | 0.520000±n/a nM | ||
Citation | Rew, Y; Sun, D; Yan, X; Beck, HP; Canon, J; Chen, A; Duquette, J; Eksterowicz, J; Fox, BM; Fu, J; Gonzalez, AZ; Houze, J; Huang, X; Jiang, M; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; Oliner, JD; Osgood, T; Saiki, AY; Shaffer, P; Wang, YC; Wortman, S; Yakowec, P; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem57:10499-511 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
E3 ubiquitin-protein ligase Mdm2 | |||
Name: | E3 ubiquitin-protein ligase Mdm2 | ||
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 55196.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q00987 | ||
Residue: | 491 | ||
Sequence: |
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BDBM50069781 | |||
n/a | |||
Name | BDBM50069781 | ||
Synonyms: | CHEMBL3407572 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H42Cl2N2O6S | ||
Mol. Mass. | 677.678 | ||
SMILES | CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(=O)N[C@H]2C[C@@H](C2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r,wU:13.41,16.18,8.8,24.27,wD:14.33,22.22,(.26,-6,;1.33,-5.39,;1.32,-6.62,;2.39,-6.01,;1.33,-3.85,;1.33,-2.62,;.26,-3.23,;2.66,-3.08,;2.67,-1.54,;4,-.77,;5.46,-.81,;4.69,.52,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;-2.39,-.13,;-1.3,-2.29,;-2.59,-3.13,;-3.69,-2.56,;-2.52,-4.66,;-3.81,-5.5,;-5.27,-5.14,;-5.6,-6.65,;-4.09,-6.98,;-6.89,-7.48,;-6.83,-8.71,;-7.98,-6.91,;,-1.54,;,-2.77,;,3.08,;-1.33,3.85,;-1.33,5.39,;0,6.16,;1.34,5.39,;2.41,6,;1.33,3.85,;2.67,1.54,;2.67,3.08,;4.01,3.85,;5.34,3.08,;6.41,3.69,;5.34,1.54,;4,.77,)| | ||
Structure |