| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
|---|
| Ligand | BDBM50075097 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1473679 (CHEMBL3421465) |
|---|
| IC50 | 2600±n/a nM |
|---|
| Citation |  Kaniskan, HÜ; Konze, KD; Jin, J Selective inhibitors of protein methyltransferases. J Med Chem58:1596-629 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-arginine methyltransferase CARM1 |
|---|
| Name: | Histone-arginine methyltransferase CARM1 |
|---|
| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 65855.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q86X55 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
|
|
|
|---|
| BDBM50075097 |
|---|
| n/a |
|---|
| Name | BDBM50075097 |
|---|
| Synonyms: | CHEMBL3414627 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H13Cl2N6NaO5S |
|---|
| Mol. Mass. | 543.315 |
|---|
| SMILES | [Na+].COc1ccc(cc1)\N=N\c1c(O)c2ccc(Nc3nc(Cl)nc(Cl)n3)cc2cc1S([O-])(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
