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TargetSET domain-containing protein 8 (SetD8)
LigandBDBM50106497
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473626
IC50 210±n/a nM
Citation Kaniskan HÜKonze KDJin J Selective inhibitors of protein methyltransferases. J Med Chem 58:1596-629 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
SET domain-containing protein 8 (SetD8)
Name:SET domain-containing protein 8 (SetD8)
Synonyms:N-lysine methyltransferase SETD8
Type:Enzyme
Mol. Mass.:42919.11
Organism:Homo sapiens (Human)
Description:Q9NQR1
Residue:393
Sequence:
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106497
n/a
NameBDBM50106497
Synonyms:6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline-5,8-dione | 6-chloro-7-(2-morpholinoethylamino)quinoline-5,8-dione | CHEMBL337173 | NSC-663284
TypeSmall organic molecule
Emp. Form.C15H16ClN3O3
Mol. Mass.321.759
SMILESOc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12 |w:6.6|
Structure
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