| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase GCN5 |
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| Ligand | BDBM50076494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473961 (CHEMBL3419557) |
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| IC50 | 260±n/a nM |
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| Citation |  Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem58:2091-113 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase GCN5 |
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| Name: | Histone acetyltransferase GCN5 |
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| Synonyms: | ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51069.24 |
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| Organism: | Saccharomyces cerevisiae S288c |
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| Description: | ChEMBL_100832 |
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| Residue: | 439 |
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| Sequence: | MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETER
IGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGL
KNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAIS
STEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGY
IKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNI
KPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEE
VPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRL
EKFFNNKVKEIPEYSHLID
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| BDBM50076494 |
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| n/a |
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| Name | BDBM50076494 |
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| Synonyms: | CHEMBL3416552 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N2O4 |
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| Mol. Mass. | 402.4425 |
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| SMILES | CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)N3C(=O)C=CC3=O)c(=O)oc2c1 |c:22| |
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| Structure | 
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