BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 613 hits with Last Name = 'strasser' and Initial = 'jm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50458516
PNG
(CHEMBL4210652)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)CCl)ccc1Cl
Show InChI InChI=1S/C10H12Cl2N2O3S/c1-14(2)18(16,17)9-5-7(3-4-8(9)12)13-10(15)6-11/h3-5H,6H2,1-2H3,(H,13,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
 440n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527166
PNG
(CHEMBL4589666)
Show SMILES FC(F)(F)c1ccc(NC(=O)CCl)cc1S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C13H14ClF3N2O4S/c14-8-12(20)18-9-1-2-10(13(15,16)17)11(7-9)24(21,22)19-3-5-23-6-4-19/h1-2,7H,3-6,8H2,(H,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
 610n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527182
PNG
(CHEMBL4458115)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)CCl)ccc1C(F)(F)F
Show InChI InChI=1S/C11H12ClF3N2O3S/c1-17(2)21(19,20)9-5-7(16-10(18)6-12)3-4-8(9)11(13,14)15/h3-5H,6H2,1-2H3,(H,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 1.20E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527163
PNG
(CHEMBL4445050)
Show SMILES COCCNS(=O)(=O)c1cc(NC(=O)CCl)ccc1Cl
Show InChI InChI=1S/C11H14Cl2N2O4S/c1-19-5-4-14-20(17,18)10-6-8(2-3-9(10)13)15-11(16)7-12/h2-3,6,14H,4-5,7H2,1H3,(H,15,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 2.50E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527184
PNG
(CHEMBL4454026)
Show SMILES CC(C)NS(=O)(=O)c1cc(NC(=O)CCl)ccc1Cl
Show InChI InChI=1S/C11H14Cl2N2O3S/c1-7(2)15-19(17,18)10-5-8(3-4-9(10)13)14-11(16)6-12/h3-5,7,15H,6H2,1-2H3,(H,14,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
 4.80E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527185
PNG
(CHEMBL4580168)
Show SMILES CN(C)S(=O)(=O)c1cc(ccc1Cl)C1CO1
Show InChI InChI=1S/C10H12ClNO3S/c1-12(2)16(13,14)10-5-7(9-6-15-9)3-4-8(10)11/h3-5,9H,6H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 5.00E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527167
PNG
(CHEMBL4445668)
Show SMILES ClCC(=O)Nc1ccc(Cl)c(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C12H14Cl2N2O4S/c13-8-12(17)15-9-1-2-10(14)11(7-9)21(18,19)16-3-5-20-6-4-16/h1-2,7H,3-6,8H2,(H,15,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
 6.70E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527162
PNG
(CHEMBL4458365)
Show SMILES COCCN(C)S(=O)(=O)c1cc(NC(=O)CCl)ccc1Cl
Show InChI InChI=1S/C12H16Cl2N2O4S/c1-16(5-6-20-2)21(18,19)11-7-9(3-4-10(11)14)15-12(17)8-13/h3-4,7H,5-6,8H2,1-2H3,(H,15,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
 6.90E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527165
PNG
(CHEMBL4554461)
Show SMILES CN(C)S(=O)(=O)c1cc(CS(F)(=O)=O)ccc1Cl
Show InChI InChI=1S/C9H11ClFNO4S2/c1-12(2)18(15,16)9-5-7(3-4-8(9)10)6-17(11,13)14/h3-5H,6H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 9.60E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Glutathione S-transferase omega-1


(Homo sapiens (Human))		BDBM50527169
PNG
(CHEMBL4437777)
Show SMILES COCCCNS(=O)(=O)c1cc(NC(=O)CCl)ccc1Cl
Show InChI InChI=1S/C12H16Cl2N2O4S/c1-20-6-2-5-15-21(18,19)11-7-9(3-4-10(11)14)16-12(17)8-13/h3-4,7,15H,2,5-6,8H2,1H3,(H,16,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 9.90E+3n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione ...

J Med Chem 63: 2894-2914 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01391
BindingDB Entry DOI: 10.7270/Q24Q7ZDQ
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50518833
PNG
(CHEMBL4528993 | US10829446, Compound 45)
Show SMILES Fc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H14FN3O3S/c19-15-11-13(17-8-4-5-9-20-17)10-14(12-15)18(23)21-22-26(24,25)16-6-2-1-3-7-16/h1-12,22H,(H,21,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 62: 7146-7159 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00665
BindingDB Entry DOI: 10.7270/Q26D5XCM
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527224
PNG
(CHEMBL4468833 | US10829446, Compound 48)
Show SMILES COc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H16FN3O4S/c1-27-15-11-13(17-7-4-5-9-21-17)10-14(12-15)19(24)22-23-28(25,26)18-8-3-2-6-16(18)20/h2-12,23H,1H3,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527244
PNG
(CHEMBL4437798 | US10829446, Compound 105)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1)-c1ccco1
Show InChI InChI=1S/C17H12ClFN2O4S/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527381
PNG
(CHEMBL4466823 | US10829446, Compound 41)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C18H14FN3O3S/c19-15-8-1-2-10-17(15)26(24,25)22-21-18(23)14-7-5-6-13(12-14)16-9-3-4-11-20-16/h1-12,22H,(H,21,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527355
PNG
(CHEMBL4456585 | US10829446, Compound 46)
Show SMILES Fc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 6.30n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527250
PNG
(CHEMBL4475883 | US10829446, Compound 67)
Show SMILES Cc1ccn(n1)-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-9-14(11-15(10-12)23-8-7-13(2)21-23)18(24)20-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,20,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527238
PNG
(CHEMBL4539384 | US10829446, Compound 42)
Show SMILES Cc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H16FN3O3S/c1-13-10-14(17-7-4-5-9-21-17)12-15(11-13)19(24)22-23-27(25,26)18-8-3-2-6-16(18)20/h2-12,23H,1H3,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50518832
PNG
(CHEMBL4455897 | US10829446, Compound 36)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-c1ccccc1
Show InChI InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 62: 7146-7159 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00665
BindingDB Entry DOI: 10.7270/Q26D5XCM
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527328
PNG
(CHEMBL4441439 | US10829446, Compound 49)
Show SMILES Cc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN4O3S/c1-12-9-13(17-20-7-4-8-21-17)11-14(10-12)18(24)22-23-27(25,26)16-6-3-2-5-15(16)19/h2-11,23H,1H3,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527245
PNG
(CHEMBL4521125 | US10829446, Compound 89)
Show SMILES Fc1cc(cc(c1)-n1nccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C15H11F2N5O3S/c16-11-7-10(8-12(9-11)22-18-5-6-19-22)15(23)20-21-26(24,25)14-4-2-1-3-13(14)17/h1-9,21H,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527225
PNG
(CHEMBL4565790 | US10829446, Compound 101)
Show SMILES Fc1cc(cc(c1)-c1ccco1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H12F2N2O4S/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.40n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50518831
PNG
(CHEMBL4464835 | US10829446, Compound 35)
Show SMILES Fc1c(Cl)cc(cc1C(=O)NNS(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H14ClFN2O3S/c20-17-12-14(13-7-3-1-4-8-13)11-16(18(17)21)19(24)22-23-27(25,26)15-9-5-2-6-10-15/h1-12,23H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 62: 7146-7159 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00665
BindingDB Entry DOI: 10.7270/Q26D5XCM
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527243
PNG
(CHEMBL4458272 | US10829446, Compound 153)
Show SMILES Cc1cc(cc(c1)-c1ccco1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN2O4S/c1-12-9-13(16-6-4-8-25-16)11-14(10-12)18(22)20-21-26(23,24)17-7-3-2-5-15(17)19/h2-11,21H,1H3,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527246
PNG
(CHEMBL4445473 | US10829446, Compound 84)
Show SMILES Cc1ccnn1-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-9-14(11-15(10-12)23-13(2)7-8-20-23)18(24)21-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527263
PNG
(CHEMBL4465716 | US10829446, Compound 63)
Show SMILES COc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O4S/c1-26-14-10-12(9-13(11-14)22-8-4-7-19-22)17(23)20-21-27(24,25)16-6-3-2-5-15(16)18/h2-11,21H,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527232
PNG
(CHEMBL4436877 | US10829446, Compound 78)
Show SMILES Cc1cnn(c1)-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-7-14(9-15(8-12)23-11-13(2)10-20-23)18(24)21-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527235
PNG
(CHEMBL4516984 | US10829446, Compound 52)
Show SMILES Fc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H12F2N4O3S/c18-13-9-11(16-20-6-3-7-21-16)8-12(10-13)17(24)22-23-27(25,26)15-5-2-1-4-14(15)19/h1-10,23H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527240
PNG
(CHEMBL4541948 | US10829446, Compound 124)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C17H13FN2O3S2/c18-15-6-1-2-7-16(15)25(22,23)20-19-17(21)13-5-3-4-12(10-13)14-8-9-24-11-14/h1-11,20H,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527366
PNG
(CHEMBL4449163 | US10829446, Compound 139)
Show SMILES CC(C)Oc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H19FN2O4S/c1-11(2)24-14-9-12(3)8-13(10-14)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h4-11,20H,1-3H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527313
PNG
(CHEMBL4446917 | US10829446, Compound 137)
Show SMILES CCOc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H17FN2O4S/c1-3-23-13-9-11(2)8-12(10-13)16(20)18-19-24(21,22)15-7-5-4-6-14(15)17/h4-10,19H,3H2,1-2H3,(H,18,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527382
PNG
(CHEMBL4518462 | US10829446, Compound 145)
Show SMILES Cc1cc(OCC=C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H17FN2O4S/c1-3-8-24-14-10-12(2)9-13(11-14)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h3-7,9-11,20H,1,8H2,2H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527277
PNG
(CHEMBL4593500)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1F)-c1ccccc1
Show InChI InChI=1S/C19H13ClF2N2O3S/c20-13-10-14(12-6-2-1-3-7-12)18(22)15(11-13)19(25)23-24-28(26,27)17-9-5-4-8-16(17)21/h1-11,24H,(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527302
PNG
(CHEMBL4573736 | US10829446, Compound 146)
Show SMILES CC(=C)COc1cc(C)c(F)c(c1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19FN2O4S/c1-12(2)11-25-14-9-13(3)17(19)16(10-14)18(22)20-21-26(23,24)15-7-5-4-6-8-15/h4-10,21H,1,11H2,2-3H3,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50518867
PNG
(CHEMBL4460509 | US10829446, Compound 157)
Show SMILES Fc1ccc(cc1C(=O)NNS(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H15FN2O3S/c20-18-12-11-15(14-7-3-1-4-8-14)13-17(18)19(23)21-22-26(24,25)16-9-5-2-6-10-16/h1-13,22H,(H,21,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 62: 7146-7159 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00665
BindingDB Entry DOI: 10.7270/Q26D5XCM
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527346
PNG
(CHEMBL4566403 | US10829446, Compound 88)
Show SMILES Cc1cc(cc(c1)-n1nccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H14FN5O3S/c1-11-8-12(10-13(9-11)22-18-6-7-19-22)16(23)20-21-26(24,25)15-5-3-2-4-14(15)17/h2-10,21H,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527251
PNG
(CHEMBL4588945 | US10829446, Compound 66)
Show SMILES Cc1ccn(n1)-c1cccc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O3S/c1-12-9-10-22(20-12)14-6-4-5-13(11-14)17(23)19-21-26(24,25)16-8-3-2-7-15(16)18/h2-11,21H,1H3,(H,19,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527358
PNG
(CHEMBL4572653 | US10829446, Compound 135)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccco1
Show InChI InChI=1S/C17H13FN2O4S/c18-14-7-1-2-9-16(14)25(22,23)20-19-17(21)13-6-3-5-12(11-13)15-8-4-10-24-15/h1-11,20H,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527365
PNG
(CHEMBL4455027 | US10829446, Compound 91)
Show SMILES Fc1cc(OCC=C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H14F2N2O4S/c1-2-7-24-13-9-11(8-12(17)10-13)16(21)19-20-25(22,23)15-6-4-3-5-14(15)18/h2-6,8-10,20H,1,7H2,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527360
PNG
(CHEMBL4456874 | US10829446, Compound 71)
Show SMILES Cc1ccn(n1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-7-23(21-11)14-9-12(8-13(18)10-14)17(24)20-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,20,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527221
PNG
(CHEMBL4464911 | US10829446, Compound 64)
Show SMILES Fc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H12F2N4O3S/c17-12-8-11(9-13(10-12)22-7-3-6-19-22)16(23)20-21-26(24,25)15-5-2-1-4-14(15)18/h1-10,21H,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527327
PNG
(CHEMBL4453559 | US10829446, Compound 55)
Show SMILES COc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN4O4S/c1-27-14-10-12(17-20-7-4-8-21-17)9-13(11-14)18(24)22-23-28(25,26)16-6-3-2-5-15(16)19/h2-11,23H,1H3,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527241
PNG
(CHEMBL4593937 | US10829446, Compound 132)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1)-c1cccs1
Show InChI InChI=1S/C17H12ClFN2O3S2/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527264
PNG
(CHEMBL4530056)
Show SMILES CCOCc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H19FN2O4S/c1-3-24-11-13-8-12(2)9-14(10-13)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h4-10,20H,3,11H2,1-2H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527242
PNG
(CHEMBL4454163 | US10829446, Compound 129)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C17H13FN2O3S2/c18-14-7-1-2-9-16(14)25(22,23)20-19-17(21)13-6-3-5-12(11-13)15-8-4-10-24-15/h1-11,20H,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527364
PNG
(CHEMBL4445456)
Show SMILES Oc1ccc(F)c(c1)S(=O)(=O)NNC(=O)c1cc(F)cc(c1)-n1cccn1
Show InChI InChI=1S/C16H12F2N4O4S/c17-11-6-10(7-12(8-11)22-5-1-4-19-22)16(24)20-21-27(25,26)15-9-13(23)2-3-14(15)18/h1-9,21,23H,(H,20,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527348
PNG
(CHEMBL4454507 | US10829446, Compound 59)
Show SMILES Cc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O3S/c1-12-9-13(11-14(10-12)22-8-4-7-19-22)17(23)20-21-26(24,25)16-6-3-2-5-15(16)18/h2-11,21H,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527265
PNG
(CHEMBL4559662 | US10829446, Compound 151)
Show SMILES Cc1cc(OC2CC2)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H17FN2O4S/c1-11-8-12(10-14(9-11)24-13-6-7-13)17(21)19-20-25(22,23)16-5-3-2-4-15(16)18/h2-5,8-10,13,20H,6-7H2,1H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)		BDBM50518832
PNG
(CHEMBL4455897 | US10829446, Compound 36)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-c1ccccc1
Show InChI InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human KAT6B (431 to end residues) expressed in baculovirus infected Sf9 insect cells using acetyl coe...

J Med Chem 62: 7146-7159 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00665
BindingDB Entry DOI: 10.7270/Q26D5XCM
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527347
PNG
(CHEMBL4526110 | US10829446, Compound 75)
Show SMILES Cc1cc(cc(c1)-n1cc(F)cn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-12(8-14(7-11)23-10-13(18)9-20-23)17(24)21-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A [507-778]


(Homo sapiens)		BDBM50527375
PNG
(CHEMBL4554392)
Show SMILES CCOCc1cc(C)c(F)c(c1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19FN2O4S/c1-3-24-11-13-9-12(2)16(18)15(10-13)17(21)19-20-25(22,23)14-7-5-4-6-8-14/h4-10,20H,3,11H2,1-2H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...

J Med Chem 63: 4655-4684 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02071
BindingDB Entry DOI: 10.7270/Q2W66Q7V
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 613 total )  |  Next  |  Last  >>
Jump to: