| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase GCN5 |
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| Ligand | BDBM50076450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473963 (CHEMBL3419559) |
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| IC50 | 1200±n/a nM |
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| Citation |  Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem58:2091-113 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase GCN5 |
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| Name: | Histone acetyltransferase GCN5 |
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| Synonyms: | ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51069.24 |
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| Organism: | Saccharomyces cerevisiae S288c |
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| Description: | ChEMBL_100832 |
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| Residue: | 439 |
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| Sequence: | MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETER
IGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGL
KNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAIS
STEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGY
IKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNI
KPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEE
VPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRL
EKFFNNKVKEIPEYSHLID
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| BDBM50076450 |
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| n/a |
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| Name | BDBM50076450 |
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| Synonyms: | CHEMBL3416537 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11BrClNO3S |
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| Mol. Mass. | 412.685 |
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| SMILES | Oc1c(Cl)cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc12 |
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| Structure | 
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