Reaction Details |
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Target | Vasopressin V1a receptor |
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Ligand | BDBM50077222 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1473358 (CHEMBL3419318) |
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Ki | 125±n/a nM |
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Citation | Ratni, H; Rogers-Evans, M; Bissantz, C; Grundschober, C; Moreau, JL; Schuler, F; Fischer, H; Alvarez Sanchez, R; Schnider, P Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem58:2275-89 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vasopressin V1a receptor |
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Name: | Vasopressin V1a receptor |
Synonyms: | AVPR V1a | Antidiuretic hormone receptor 1a | Avpr1a | V1AR_MOUSE | V1aR | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1a receptor |
Type: | PROTEIN |
Mol. Mass.: | 47202.75 |
Organism: | Mus musculus |
Description: | ChEMBL_109593 |
Residue: | 423 |
Sequence: | MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAV
IFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGP
DWLCRVVKHLQVFAMFASSYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAASWGLSFV
LSIPQYFIFSVIEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGF
ICYHIWRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFV
IVSAYILCWTPFFIVQMWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHL
LQDCVQSFPCCQSIAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGTWKDSPKSSKSIRFIP
VST
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BDBM50077222 |
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n/a |
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Name | BDBM50077222 |
Synonyms: | CHEMBL3416882 |
Type | Small organic molecule |
Emp. Form. | C26H28ClN3O2 |
Mol. Mass. | 449.972 |
SMILES | Clc1ccc2c(cn(C[C@@H]3CCCN3)c2c1)C(=O)N1CCC2(CC1)OCc1ccccc21 |r| |
Structure |
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