Reaction Details |
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Target | Arachidonate 5-lipoxygenase-activating protein |
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Ligand | BDBM50078045 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1471926 (CHEMBL3420841) |
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IC50 | >5000±n/a nM |
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Citation | Takahashi, H; Riether, D; Bartolozzi, A; Bosanac, T; Berger, V; Binetti, R; Broadwater, J; Chen, Z; Crux, R; De Lombaert, S; Dave, R; Dines, JA; Fadra-Khan, T; Flegg, A; Garrigou, M; Hao, MH; Huber, J; Hutzler, JM; Kerr, S; Kotey, A; Liu, W; Lo, HY; Loke, PL; Mahaney, PE; Morwick, TM; Napier, S; Olague, A; Pack, E; Padyana, AK; Thomson, DS; Tye, H; Wu, L; Zindell, RM; Abeywardane, A; Simpson, T Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem58:1669-90 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Arachidonate 5-lipoxygenase-activating protein |
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Name: | Arachidonate 5-lipoxygenase-activating protein |
Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
Type: | Enzyme |
Mol. Mass.: | 18159.90 |
Organism: | Homo sapiens (Human) |
Description: | P20292 |
Residue: | 161 |
Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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BDBM50078045 |
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n/a |
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Name | BDBM50078045 |
Synonyms: | CHEMBL3417421 |
Type | Small organic molecule |
Emp. Form. | C21H18N6O2 |
Mol. Mass. | 386.4066 |
SMILES | Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1ccc[nH]c1=O |
Structure |
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