| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase |
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| Ligand | BDBM50078850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1472471 |
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| IC50 | 60±n/a nM |
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| Citation |  Filosa R; Peduto A; Schaible AM; Krauth V; Weinigel C; Barz D; Petronzi C; Bruno F; Roviezzo F; Spaziano G; D'Agostino B; De Rosa M; Werz O Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. Eur J Med Chem 94:132-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase |
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| Name: | Arachidonate 5-lipoxygenase |
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| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | ALOX5 | LOG5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 77972.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
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| Residue: | 674 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG
CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE
AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY
YYLSPDRIPNSVAI
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| BDBM50078850 |
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| n/a |
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| Name | BDBM50078850 |
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| Synonyms: | CHEBI:4778 | EMBELIN | Embelin |
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| Type | Small organic molecule |
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| Emp. Form. | C17H26O4 |
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| Mol. Mass. | 294.3859 |
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| SMILES | CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O |c:11,t:16| |
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| Structure | 
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