| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
|---|
| Ligand | BDBM50282506 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1471139 (CHEMBL3421029) |
|---|
| IC50 | 0.900000±n/a nM |
|---|
| Citation |  Xie, SS; Wang, X; Jiang, N; Yu, W; Wang, KD; Lan, JS; Li, ZR; Kong, LY Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. Eur J Med Chem95:153-65 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] B |
|---|
| Name: | Amine oxidase [flavin-containing] B |
|---|
| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58768.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27338 |
|---|
| Residue: | 520 |
|---|
| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
|
|
|
|---|
| BDBM50282506 |
|---|
| n/a |
|---|
| Name | BDBM50282506 |
|---|
| Synonyms: | 7-(5-Isopropyl-[1,3,4]thiadiazol-2-ylmethoxy)-3,4-dimethyl-chromen-2-one | Atibeprone | CHEMBL19004 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18N2O3S |
|---|
| Mol. Mass. | 330.401 |
|---|
| SMILES | CC(C)c1nnc(COc2ccc3c(C)c(C)c(=O)oc3c2)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
