Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50081114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1475560 (CHEMBL3424621) |
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EC50 | 14000±n/a nM |
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Citation | Duan, H; Ning, M; Zou, Q; Ye, Y; Feng, Y; Zhang, L; Leng, Y; Shen, J Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes. J Med Chem58:3315-28 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | GPBAR_MOUSE | Gpbar1 | M-BAR | Membrane-type receptor for bile acids | Tgr5 |
Type: | PROTEIN |
Mol. Mass.: | 35665.78 |
Organism: | Mus musculus |
Description: | ChEMBL_1475560 |
Residue: | 329 |
Sequence: | MMTPNSTELSAIPMGVLGLSLALASLIVIANLLLALGIALDRHLRSPPAGCFFLSLLLAG
LLTGLALPMLPGLWSRNHQGYWSCLLLHLTPNFCFLSLLANLLLVHGERYMAVLQPLRPH
GSVRLALFLTWVSSLFFASLPALGWNHWSPDANCSSQAVFPAPYLYLEVYGLLLPAVGAT
ALLSVRVLATAHRQLCEIRRLERAVCRDVPSTLARALTWRQARAQAGATLLFLLCWGPYV
ATLLLSVLAYERRPPLGPGTLLSLISLGSTSAAAVPVAMGLGDQRYTAPWRTAAQRCLRV
LRGRAKRDNPGPSTAYHTSSQCSIDLDLN
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BDBM50081114 |
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n/a |
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Name | BDBM50081114 |
Synonyms: | CHEMBL3421902 |
Type | Small organic molecule |
Emp. Form. | C60H62Cl4N8O9 |
Mol. Mass. | 1180.994 |
SMILES | Clc1cc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc23)c(Cl)cc1CCC(=O)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc23)cc1Cl |
Structure |
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