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TargetCoagulation factor XIII A chain
LigandBDBM50009248
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1475035 (CHEMBL3424606)
IC50 4000±n/a nM
Citation Avery, CAPease, RJSmith, KBoothby, MBuckley, HMGrant, PJFishwick, CW (±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors. Eur J Med Chem98:49-53 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XIII A chain
Name:Coagulation factor XIII A chain
Synonyms:Coagulation factor XIII | F13A | F13A1 | F13A_HUMAN
Type:PROTEIN
Mol. Mass.:83261.29
Organism:Homo sapiens (Human)
Description:ChEMBL_1475048
Residue:732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50009248
n/a
NameBDBM50009248
Synonyms:(2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide | (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide | 3-Nona-4,7-dienoyl-oxirane-2-carboxylic acid amide | 3-Nona-4,7-dienoyl-oxirane-2-carboxylic acid amide(Cerulenin) | CERULENIN | CHEMBL45627
TypeSmall organic molecule
Emp. Form.C12H17NO3
Mol. Mass.223.2683
SMILESC\C=C\C\C=C\CCC(=O)[C@H]1O[C@H]1C(N)=O |r|
Structure
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