Reaction Details |
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Target | Hematopoietic prostaglandin D synthase |
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Ligand | BDBM50084153 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1477159 (CHEMBL3428468) |
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IC50 | 210±n/a nM |
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Citation | Edfeldt, F; Evenäs, J; Lepistö, M; Ward, A; Petersen, J; Wissler, L; Rohman, M; Sivars, U; Svensson, K; Perry, M; Feierberg, I; Zhou, XH; Hansson, T; Narjes, F Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett25:2496-500 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Hematopoietic prostaglandin D synthase |
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Name: | Hematopoietic prostaglandin D synthase |
Synonyms: | GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase |
Type: | Enzyme |
Mol. Mass.: | 23341.07 |
Organism: | Homo sapiens (Human) |
Description: | The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag. |
Residue: | 199 |
Sequence: | MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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BDBM50084153 |
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n/a |
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Name | BDBM50084153 |
Synonyms: | CHEMBL3425948 |
Type | Small organic molecule |
Emp. Form. | C20H22F3N3O2 |
Mol. Mass. | 393.4028 |
SMILES | COc1cccc(c1)-c1ccc(cn1)C(=O)NC1CCN(CC(F)(F)F)CC1 |
Structure |
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