| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin-like domain-containing CTD phosphatase 1 |
|---|
| Ligand | BDBM50087862 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1476058 (CHEMBL3428554) |
|---|
| pH | 6±n/a |
|---|
| IC50 | 4200±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  He, Y; Guo, X; Yu, ZH; Wu, L; Gunawan, AM; Zhang, Y; Dixon, JE; Zhang, ZY A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorg Med Chem23:2798-809 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin-like domain-containing CTD phosphatase 1 |
|---|
| Name: | Ubiquitin-like domain-containing CTD phosphatase 1 |
|---|
| Synonyms: | Nuclear proteasome inhibitor UBLCP1 | UBCP1_HUMAN | UBLCP1 | Ubiquitin-like domain-containing CTD phosphatase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36803.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8WVY7 |
|---|
| Residue: | 318 |
|---|
| Sequence: | MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQKLLGLKVKGKPAENDVK
LGALKLKPNTKIMMMGTREESLEDVLGPPPDNDDVVNDFDIEDEVVEVENREENLLKISR
RVKEYKVEILNPPREGKKLLVLDVDYTLFDHRSCAETGVELMRPYLHEFLTSAYEDYDIV
IWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIDVKPLGVIWGKFS
EFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELLKLTQYLKEIAKLDDF
LDLNHKYWERYLSKKQGQ
|
|
|
|---|
| BDBM50087862 |
|---|
| n/a |
|---|
| Name | BDBM50087862 |
|---|
| Synonyms: | CHEMBL3426911 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H33NO6 |
|---|
| Mol. Mass. | 563.6396 |
|---|
| SMILES | CCCCC(Oc1cc(O)c(cc1C#Cc1ccc(CO)cc1)C(O)=O)C(=O)NC(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
