| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hexokinase-4 |
|---|
| Ligand | BDBM50089138 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1495696 (CHEMBL3578684) |
|---|
| EC50 | 1870±n/a nM |
|---|
| Citation |  Park, K; Lee, BM; Hyun, KH; Han, T; Lee, DH; Choi, HH Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM. ACS Med Chem Lett6:296-301 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hexokinase-4 |
|---|
| Name: | Hexokinase-4 |
|---|
| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52175.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35557 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
|
|
|
|---|
| BDBM50089138 |
|---|
| n/a |
|---|
| Name | BDBM50089138 |
|---|
| Synonyms: | CHEMBL3577714 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23N3O4 |
|---|
| Mol. Mass. | 357.4036 |
|---|
| SMILES | COCC#Cc1cc(O[C@@H](C)COC)cc(c1)C(=O)Nc1ccn(C)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
