| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
|---|
| Ligand | BDBM50098591 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1504786 (CHEMBL3595071) |
|---|
| Ki | 2800±n/a nM |
|---|
| Citation |  Priestley, ES; Cheney, DL; DeLucca, I; Wei, A; Luettgen, JM; Rendina, AR; Wong, PC; Wexler, RR Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors. J Med Chem58:6225-36 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vitamin K-dependent protein C |
|---|
| Name: | Vitamin K-dependent protein C |
|---|
| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52067.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 461 |
|---|
| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
|
|
|
|---|
| BDBM50098591 |
|---|
| n/a |
|---|
| Name | BDBM50098591 |
|---|
| Synonyms: | CHEMBL3594305 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27N5O2 |
|---|
| Mol. Mass. | 465.5463 |
|---|
| SMILES | Nc1nccc2cc(N[C@@H]3c4ccc(CCCC(=O)Nc5cccc(CNC3=O)c5)cc4)ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
