Reaction Details |
| Report a problem with these data |
Target | Signal transducer and activator of transcription 3 |
---|
Ligand | BDBM196138 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1436271 (CHEMBL3387771) |
---|
IC50 | 800±n/a nM |
---|
Citation | LaPorte, MG; da Paz Lima, DJ; Zhang, F; Sen, M; Grandis, JR; Camarco, D; Hua, Y; Johnston, PA; Lazo, JS; Resnick, LO; Wipf, P; Huryn, DM 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorg Med Chem Lett24:5081-5 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Signal transducer and activator of transcription 3 |
---|
Name: | Signal transducer and activator of transcription 3 |
Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
Type: | Protein |
Mol. Mass.: | 88064.31 |
Organism: | Homo sapiens (Human) |
Description: | P40763 |
Residue: | 770 |
Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
|
|
|
BDBM196138 |
---|
n/a |
---|
Name | BDBM196138 |
Synonyms: | US9211296, Table 7, Compd: 9 |
Type | Small organic molecule |
Emp. Form. | C18H23N5 |
Mol. Mass. | 309.4087 |
SMILES | CC1=CC(C)(C)N=C(Nc2nc(C)c3cc(C)cc(C)c3n2)N1 |t:1,6| |
Structure |
|