Reaction Details | |||
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Target | Receptor-type tyrosine-protein kinase FLT3 | ||
Ligand | BDBM50103899 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1505177 (CHEMBL3594719) | ||
IC50 | 134±n/a nM | ||
Citation | Liao, W; Hu, G; Guo, Z; Sun, D; Zhang, L; Bu, Y; Li, Y; Liu, Y; Gong, P Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitors. Bioorg Med Chem23:4410-22 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Receptor-type tyrosine-protein kinase FLT3 | |||
Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 112888.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36888 | ||
Residue: | 993 | ||
Sequence: |
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BDBM50103899 | |||
n/a | |||
Name | BDBM50103899 | ||
Synonyms: | CHEMBL3594105 | ||
Type | Small organic molecule | ||
Emp. Form. | C35H36ClFN6O5 | ||
Mol. Mass. | 675.149 | ||
SMILES | COc1cc2c(Oc3ccc(NC(=O)c4[nH]c(=O)n(c4C)-c4ccccc4Cl)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 |(3.99,-2.77,;3.99,-1.54,;2.66,-.77,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-1.33,-3.08,;-2.66,-3.85,;-3.99,-3.09,;-5.32,-3.86,;-5.32,-5.4,;-6.65,-6.18,;-6.64,-7.72,;-5.58,-8.33,;-7.98,-8.49,;-9.36,-7.86,;-10.39,-9.01,;-11.62,-8.88,;-9.62,-10.34,;-8.11,-10.02,;-7.19,-10.83,;-10.24,-11.75,;-9.24,-12.92,;-9.75,-14.37,;-11.27,-14.65,;-12.27,-13.48,;-11.75,-12.03,;-12.55,-11.09,;-3.98,-6.17,;-2.65,-5.39,;-1.58,-6.01,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.99,1.54,;3.99,3.08,;5.33,3.86,;5.32,5.4,;6.66,6.17,;6.66,7.71,;7.99,8.48,;9.32,7.71,;10.39,8.33,;9.32,6.17,;7.99,5.4,)| | ||
Structure |