Reaction Details | |||
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Target | Hepatocyte growth factor receptor | ||
Ligand | BDBM50103903 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1505168 (CHEMBL3594710) | ||
IC50 | 11±n/a nM | ||
Citation | Liao, W; Hu, G; Guo, Z; Sun, D; Zhang, L; Bu, Y; Li, Y; Liu, Y; Gong, P Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitors. Bioorg Med Chem23:4410-22 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Hepatocyte growth factor receptor | |||
Name: | Hepatocyte growth factor receptor | ||
Synonyms: | Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase | ||
Type: | Protein | ||
Mol. Mass.: | 155559.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08581 | ||
Residue: | 1390 | ||
Sequence: |
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BDBM50103903 | |||
n/a | |||
Name | BDBM50103903 | ||
Synonyms: | CHEMBL3594101 | ||
Type | Small organic molecule | ||
Emp. Form. | C38H39F4N5O5 | ||
Mol. Mass. | 721.7404 | ||
SMILES | COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(-c5ccccc5C(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 |(3.99,-2.77,;3.99,-1.54,;2.66,-.77,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-1.33,-3.08,;-2.66,-3.85,;-3.99,-3.09,;-5.32,-3.86,;-5.32,-5.4,;-6.65,-6.18,;-6.64,-7.72,;-5.58,-8.33,;-7.98,-8.49,;-9.36,-7.86,;-9.62,-6.65,;-10.39,-9.01,;-11.92,-8.85,;-12.44,-7.4,;-13.96,-7.13,;-14.95,-8.3,;-14.43,-9.75,;-12.91,-10.02,;-12.39,-11.47,;-11.18,-11.69,;-13.18,-12.41,;-11.97,-12.63,;-9.62,-10.34,;-10.12,-11.47,;-8.11,-10.02,;-7.19,-10.83,;-3.98,-6.17,;-2.65,-5.39,;-1.58,-6.01,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;3.99,1.54,;3.99,3.08,;5.33,3.86,;5.32,5.4,;6.66,6.17,;6.66,7.71,;7.99,8.48,;9.32,7.71,;10.39,8.33,;9.32,6.17,;7.99,5.4,)| | ||
Structure |