| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Ligand | BDBM50104766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1506153 (CHEMBL3594629) |
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| IC50 | 12600±n/a nM |
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| Citation |  Wang, K; Bao, L; Xiong, W; Ma, K; Han, J; Wang, W; Yin, W; Liu, H Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase anda-Glucosidase. J Nat Prod78:1977-89 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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| Synonyms: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMDH_PIG | HMG-CoA reductase | HMGCR | HMGR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97149.70 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_109835 |
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| Residue: | 885 |
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| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
QKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETDTSSRPTFVVGNS
TLDSSLELEMQEPEIQIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTPVVRFPRACDSA
EVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKG
TEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKT
TTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEA
SGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVC
GTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
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| BDBM50104766 |
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| n/a |
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| Name | BDBM50104766 |
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| Synonyms: | CHEMBL3594158 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H46O4 |
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| Mol. Mass. | 470.6838 |
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| SMILES | [H][C@@]1([#6]-[#6][C@@]2([#6])[#6]-3=[#6](-[#6]-[#6][C@]12[#6])[C@@]1([#6])[#6]-[#6]-[#6](=O)C([#6])([#6])[C@]1([H])[#6]-[#6]-3=O)[#6@H](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6]-[#8])-[#6]-[#8] |r,c:6| |
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| Structure | 
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