| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
|---|
| Ligand | BDBM50115192 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1513495 (CHEMBL3611851) |
|---|
| EC50 | 1300±n/a nM |
|---|
| Citation |  Matsui, Y; Yamaguchi, T; Yamazaki, T; Yoshida, M; Arai, M; Terasaka, N; Honzumi, S; Wakabayashi, K; Hayashi, S; Nakai, D; Hanzawa, H; Tamaki, K Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists. Bioorg Med Chem Lett25:3914-20 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Oxysterols receptor LXR-alpha |
|---|
| Name: | Oxysterols receptor LXR-alpha |
|---|
| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50403.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13133 |
|---|
| Residue: | 447 |
|---|
| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
|
|
|
|---|
| BDBM50115192 |
|---|
| n/a |
|---|
| Name | BDBM50115192 |
|---|
| Synonyms: | CHEMBL3609572 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H25F3O6 |
|---|
| Mol. Mass. | 502.479 |
|---|
| SMILES | CC(C)(C)OC(=O)c1c(O)c(ccc1COc1ccc(cc1)-c1cccc(CC(O)=O)c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
