Ki Summary

Reaction Details

Report a problem with these data

Target

Hepatocyte growth factor receptor

Ligand

BDBM50115208

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1513739 (CHEMBL3610849)

IC50

350±n/a nM

Citation

Raeppel, F; Raeppel, SL; Therrien, E Design, synthesis and RON receptor tyrosine kinase inhibitory activity of new head groups analogs of LCRF-0004. Bioorg Med Chem Lett25:3810-5 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hepatocyte growth factor receptor

Name:

Hepatocyte growth factor receptor

Synonyms:

Type:

Protein

Mol. Mass.:

155559.73

Organism:

Homo sapiens (Human)

Description:

P08581

Residue:

1390

Sequence:

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS

BDBM50115208

n/a

Name

BDBM50115208

Synonyms:

CHEMBL3608548

Type

Small organic molecule

Emp. Form.

C34H25FN6O3S

Mol. Mass.

616.664

SMILES

COc1ccccc1-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 |(-3.55,-8.91,;-4.74,-9.2,;-5.17,-10.68,;-4.1,-11.79,;-4.53,-13.27,;-6.02,-13.64,;-7.09,-12.53,;-6.66,-11.05,;-7.81,-10.03,;-7.67,-8.51,;-9.06,-7.88,;-10.09,-9.02,;-9.32,-10.35,;-9.94,-11.76,;-9.13,-13.07,;-9.86,-14.43,;-11.4,-14.47,;-12.21,-13.17,;-11.48,-11.81,;-6.34,-7.73,;-5.27,-8.35,;-6.35,-6.19,;-5.02,-5.42,;-5.02,-3.88,;-3.69,-3.1,;-2.35,-3.87,;-1.02,-3.09,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;4.2,.03,;4.99,-1.28,;6.48,-.91,;7.42,-1.7,;6.59,.63,;5.16,1.21,;-2.35,-5.41,;-1.28,-6.02,;-3.68,-6.18,)|

Structure