Found 69 hits with Last Name = 'raeppel' and Initial = 'sl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93149
(2-oxoimidazolidine-1-carboxamide, 16)Show SMILES CNC(=O)Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)cc2)ccn1 Show InChI InChI=1S/C23H21FN6O4/c1-25-21(31)28-20-14-19(10-11-26-20)34-18-8-4-16(5-9-18)27-22(32)30-13-12-29(23(30)33)17-6-2-15(24)3-7-17/h2-11,14H,12-13H2,1H3,(H,27,32)(H2,25,26,28,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93147
(2-oxoimidazolidine-1-carboxamide, 14)Show SMILES CC(=O)Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)cc2)ccn1 Show InChI InChI=1S/C23H20FN5O4/c1-15(30)26-21-14-20(10-11-25-21)33-19-8-4-17(5-9-19)27-22(31)29-13-12-28(23(29)32)18-6-2-16(24)3-7-18/h2-11,14H,12-13H2,1H3,(H,27,31)(H,25,26,30) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93150
(2-oxoimidazolidine-1-carboxamide, 17)Show SMILES Fc1ccc(cc1)N1CCN(C(=O)Nc2ccc(Oc3ccnc(NC(=O)NCCN4CCCC4)c3)cc2)C1=O Show InChI InChI=1S/C28H30FN7O4/c29-20-3-7-22(8-4-20)35-17-18-36(28(35)39)27(38)32-21-5-9-23(10-6-21)40-24-11-12-30-25(19-24)33-26(37)31-13-16-34-14-1-2-15-34/h3-12,19H,1-2,13-18H2,(H,32,38)(H2,30,31,33,37) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93145
(2-oxoimidazolidine-1-carboxamide, 5)Show SMILES CC(=O)Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccccc3)cc2)ccn1 Show InChI InChI=1S/C23H21N5O4/c1-16(29)25-21-15-20(11-12-24-21)32-19-9-7-17(8-10-19)26-22(30)28-14-13-27(23(28)31)18-5-3-2-4-6-18/h2-12,15H,13-14H2,1H3,(H,26,30)(H,24,25,29) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93148
(2-oxoimidazolidine-1-carboxamide, 15)Show SMILES CNC(=O)Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccccc3)cc2)ccn1 Show InChI InChI=1S/C23H22N6O4/c1-24-21(30)27-20-15-19(11-12-25-20)33-18-9-7-16(8-10-18)26-22(31)29-14-13-28(23(29)32)17-5-3-2-4-6-17/h2-12,15H,13-14H2,1H3,(H,26,31)(H2,24,25,27,30) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115202
(CHEMBL3608550)Show SMILES COc1cccc(c1)-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 Show InChI InChI=1S/C34H25FN6O3S/c1-40-19-28(37-20-40)31-17-27-33(45-31)30(13-14-36-27)44-29-12-11-22(16-26(29)35)39-34(42)25-18-38-41(23-8-4-3-5-9-23)32(25)21-7-6-10-24(15-21)43-2/h3-20H,1-2H3,(H,39,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met kinase domain |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247984
(CHEMBL453613 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-16-22(31-17-33)25-15-21-26(39-25)24(10-11-30-21)38-23-9-8-18(14-20(23)29)32-27(36)35-13-12-34(28(35)37)19-6-4-3-5-7-19/h3-11,14-17H,2,12-13H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50091030
(CHEMBL3582033)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ccn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/p+1/t10-,13-/m1/s1 | PDB
KEGG
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115203
(CHEMBL3608551)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4cccnc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-15-25-31(43-29)28(11-13-35-25)42-27-10-9-21(14-24(27)33)38-32(41)23-17-37-40(22-7-3-2-4-8-22)30(23)20-6-5-12-34-16-20/h2-19H,1H3,(H,38,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met kinase domain |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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PC sid
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090969
(CHEMBL3582034)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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| CHEMBL
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115203
(CHEMBL3608551)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4cccnc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-15-25-31(43-29)28(11-13-35-25)42-27-10-9-21(14-24(27)33)38-32(41)23-17-37-40(22-7-3-2-4-8-22)30(23)20-6-5-12-34-16-20/h2-19H,1H3,(H,38,41) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317324
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37) | PDB
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| CHEMBL
PC cid
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| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090968
(CHEMBL3582035)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247984
(CHEMBL453613 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-16-22(31-17-33)25-15-21-26(39-25)24(10-11-30-21)38-23-9-8-18(14-20(23)29)32-27(36)35-13-12-34(28(35)37)19-6-4-3-5-7-19/h3-11,14-17H,2,12-13H2,1H3,(H,32,36) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM93146
(2-oxoimidazolidine-1-carboxamide, 13)Show SMILES Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccccc3)cc2)ccn1 Show InChI InChI=1S/C21H19N5O3/c22-19-14-18(10-11-23-19)29-17-8-6-15(7-9-17)24-20(27)26-13-12-25(21(26)28)16-4-2-1-3-5-16/h1-11,14H,12-13H2,(H2,22,23)(H,24,27) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115201
(CHEMBL3608544)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C33H23FN6O2S/c1-39-19-27(36-20-39)30-17-26-32(43-30)29(14-15-35-26)42-28-13-12-22(16-25(28)34)38-33(41)24-18-37-40(23-10-6-3-7-11-23)31(24)21-8-4-2-5-9-21/h2-20H,1H3,(H,38,41) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115196
(CHEMBL3608549)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccn4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-16-25-31(43-29)28(12-14-35-25)42-27-11-10-20(15-23(27)33)38-32(41)22-17-37-40(21-7-3-2-4-8-21)30(22)24-9-5-6-13-34-24/h2-19H,1H3,(H,38,41) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115197
(CHEMBL3608547)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccccc4F)-c4ccccc4)cc3F)c2s1 |(7.42,-1.7,;6.48,-.91,;6.59,.63,;5.16,1.21,;4.2,.03,;4.99,-1.28,;2.66,.02,;1.76,1.24,;.3,.77,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;-1.02,-3.09,;-2.35,-3.87,;-3.69,-3.1,;-5.02,-3.88,;-5.02,-5.42,;-6.35,-6.19,;-6.34,-7.73,;-5.27,-8.35,;-7.67,-8.51,;-9.06,-7.88,;-10.09,-9.02,;-9.32,-10.35,;-7.81,-10.03,;-6.66,-11.05,;-7.09,-12.53,;-6.02,-13.64,;-4.53,-13.27,;-4.1,-11.79,;-5.17,-10.68,;-4.83,-9.5,;-9.94,-11.76,;-9.13,-13.07,;-9.86,-14.43,;-11.4,-14.47,;-12.21,-13.17,;-11.48,-11.81,;-3.68,-6.18,;-2.35,-5.41,;-1.28,-6.02,;.3,-.77,;1.76,-1.24,)| Show InChI InChI=1S/C33H22F2N6O2S/c1-40-18-27(37-19-40)30-16-26-32(44-30)29(13-14-36-26)43-28-12-11-20(15-25(28)35)39-33(42)23-17-38-41(21-7-3-2-4-8-21)31(23)22-9-5-6-10-24(22)34/h2-19H,1H3,(H,39,42) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115202
(CHEMBL3608550)Show SMILES COc1cccc(c1)-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 Show InChI InChI=1S/C34H25FN6O3S/c1-40-19-28(37-20-40)31-17-27-33(45-31)30(13-14-36-27)44-29-12-11-22(16-26(29)35)39-34(42)25-18-38-41(23-8-4-3-5-9-23)32(25)21-7-6-10-24(15-21)43-2/h3-20H,1-2H3,(H,39,42) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON phosphorylation in human HT29 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
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ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON phosphorylation in human PC3 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM93143
(Oxo-3-phenylimidazolidine-1-carboxamide, 4)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc(NC(=O)N2CCCC2)c1 Show InChI InChI=1S/C26H25FN6O4/c27-21-16-18(29-25(35)33-15-14-32(26(33)36)19-6-2-1-3-7-19)8-9-22(21)37-20-10-11-28-23(17-20)30-24(34)31-12-4-5-13-31/h1-3,6-11,16-17H,4-5,12-15H2,(H,29,35)(H,28,30,34) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50114398
(CHEMBL3609808)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C29H21FN6O2S/c1-34-16-23(32-17-34)27-14-22-28(39-27)26(9-11-31-22)38-25-8-7-19(13-21(25)30)35-12-10-24-20(29(35)37)15-33-36(24)18-5-3-2-4-6-18/h2-9,11,13-17H,10,12H2,1H3 | PDB
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Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115200
(CHEMBL3608545)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4-c4ccccc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C33H23FN6O2S/c1-39-19-27(36-20-39)30-17-26-32(43-30)29(14-15-35-26)42-28-13-12-22(16-25(28)34)37-33(41)24-18-40(23-10-6-3-7-11-23)38-31(24)21-8-4-2-5-9-21/h2-20H,1H3,(H,37,41) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50114396
(CHEMBL3609807)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCCc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C30H23FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-4,6-7,9-12,14-18H,5,8,13H2,1H3 | PDB
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Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090966
(CHEMBL3582037)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40) | PDB
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ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115199
(CHEMBL3608312)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4sc(nc4-c4ccccc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C33H22FN5O2S2/c1-39-18-25(36-19-39)28-17-24-30(42-28)27(14-15-35-24)41-26-13-12-22(16-23(26)34)37-32(40)31-29(20-8-4-2-5-9-20)38-33(43-31)21-10-6-3-7-11-21/h2-19H,1H3,(H,37,40) | PDB
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Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50114394
(CHEMBL3609805)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CC=Cc4c(cnn4-c4ccccc4)C3=O)c2s1 |c:25| Show InChI InChI=1S/C30H21FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-12,14-18H,13H2,1H3 | PDB
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Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM93142
(Oxo-3-phenylimidazolidine-1-carboxamide, 3)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1cc(NC(=O)N2CCCC2)ncn1 Show InChI InChI=1S/C25H24FN7O4/c26-19-14-17(29-24(35)33-13-12-32(25(33)36)18-6-2-1-3-7-18)8-9-20(19)37-22-15-21(27-16-28-22)30-23(34)31-10-4-5-11-31/h1-3,6-9,14-16H,4-5,10-13H2,(H,29,35)(H,27,28,30,34) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50114398
(CHEMBL3609808)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C29H21FN6O2S/c1-34-16-23(32-17-34)27-14-22-28(39-27)26(9-11-31-22)38-25-8-7-19(13-21(25)30)35-12-10-24-20(29(35)37)15-33-36(24)18-5-3-2-4-6-18/h2-9,11,13-17H,10,12H2,1H3 | PDB
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50090967
(CHEMBL3582036)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)35-27(39)18-13-38(17-5-3-2-4-6-17)36-26(18)28(30,31)32/h2-15H,1H3,(H,35,39) | PDB
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| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50115198
(CHEMBL3608546)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cc(-c5ccccc5)n(c4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C34H24FN5O2S/c1-39-20-28(37-21-39)32-18-27-33(43-32)31(14-15-36-27)42-30-13-12-24(17-26(30)35)38-34(41)23-16-29(22-8-4-2-5-9-22)40(19-23)25-10-6-3-7-11-25/h2-21H,1H3,(H,38,41) | PDB
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| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50114396
(CHEMBL3609807)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CCCc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C30H23FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-4,6-7,9-12,14-18H,5,8,13H2,1H3 | PDB
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| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM93142
(Oxo-3-phenylimidazolidine-1-carboxamide, 3)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1cc(NC(=O)N2CCCC2)ncn1 Show InChI InChI=1S/C25H24FN7O4/c26-19-14-17(29-24(35)33-13-12-32(25(33)36)18-6-2-1-3-7-18)8-9-20(19)37-22-15-21(27-16-28-22)30-23(34)31-10-4-5-11-31/h1-3,6-9,14-16H,4-5,10-13H2,(H,29,35)(H,27,28,30,34) | PDB
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MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115204
(CHEMBL3608552)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccc(F)cc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C33H22F2N6O2S/c1-40-18-27(37-19-40)30-16-26-32(44-30)29(13-14-36-26)43-28-12-11-22(15-25(28)35)39-33(42)24-17-38-41(23-5-3-2-4-6-23)31(24)20-7-9-21(34)10-8-20/h2-19H,1H3,(H,39,42) | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50114393
(CHEMBL3609806)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CC(=O)Nc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C29H20FN7O3S/c1-35-14-22(32-16-35)25-12-21-27(41-25)24(9-10-31-21)40-23-8-7-18(11-20(23)30)36-15-26(38)34-28-19(29(36)39)13-33-37(28)17-5-3-2-4-6-17/h2-14,16H,15H2,1H3,(H,34,38) | PDB
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| n/a | n/a | 207 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115203
(CHEMBL3608551)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4cccnc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C32H22FN7O2S/c1-39-18-26(36-19-39)29-15-25-31(43-29)28(11-13-35-25)42-27-10-9-21(14-24(27)33)38-32(41)23-17-37-40(22-7-3-2-4-8-22)30(23)20-6-5-12-34-16-20/h2-19H,1H3,(H,38,41) | PDB
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM93143
(Oxo-3-phenylimidazolidine-1-carboxamide, 4)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc(NC(=O)N2CCCC2)c1 Show InChI InChI=1S/C26H25FN6O4/c27-21-16-18(29-25(35)33-15-14-32(26(33)36)19-6-2-1-3-7-19)8-9-22(21)37-20-10-11-28-23(17-20)30-24(34)31-12-4-5-13-31/h1-3,6-11,16-17H,4-5,12-15H2,(H,29,35)(H,28,30,34) | PDB
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| | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115202
(CHEMBL3608550)Show SMILES COc1cccc(c1)-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 Show InChI InChI=1S/C34H25FN6O3S/c1-40-19-28(37-20-40)31-17-27-33(45-31)30(13-14-36-27)44-29-12-11-22(16-26(29)35)39-34(42)25-18-38-41(23-8-4-3-5-9-23)32(25)21-7-6-10-24(15-21)43-2/h3-20H,1-2H3,(H,39,42) | PDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50114394
(CHEMBL3609805)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CC=Cc4c(cnn4-c4ccccc4)C3=O)c2s1 |c:25| Show InChI InChI=1S/C30H21FN6O2S/c1-35-17-24(33-18-35)28-15-23-29(40-28)27(11-12-32-23)39-26-10-9-20(14-22(26)31)36-13-5-8-25-21(30(36)38)16-34-37(25)19-6-3-2-4-7-19/h2-12,14-18H,13H2,1H3 | PDB
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| n/a | n/a | 304 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM93144
(Oxo-3-phenylimidazolidine-1-carboxamide, 5)Show SMILES CC(=O)Nc1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccccc3)cc2F)ccn1 Show InChI InChI=1S/C23H20FN5O4/c1-15(30)26-21-14-18(9-10-25-21)33-20-8-7-16(13-19(20)24)27-22(31)29-12-11-28(23(29)32)17-5-3-2-4-6-17/h2-10,13-14H,11-12H2,1H3,(H,27,31)(H,25,26,30) | PDB
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| | n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
| Assay Description
Inhibition assay using kinase inhibitors. |
International Journal of Medicinal Chemistry 2012: 1-6 (2012)
BindingDB Entry DOI: 10.7270/Q2X065P9 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115207
(CHEMBL3608707)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4-c4ccsc4)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C31H21FN6O2S2/c1-37-16-25(34-18-37)28-14-24-30(42-28)27(9-11-33-24)40-26-8-7-20(13-23(26)32)36-31(39)22-15-35-38(21-5-3-2-4-6-21)29(22)19-10-12-41-17-19/h2-18H,1H3,(H,36,39) | PDB
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50115208
(CHEMBL3608548)Show SMILES COc1ccccc1-c1c(cnn1-c1ccccc1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1 |(-3.55,-8.91,;-4.74,-9.2,;-5.17,-10.68,;-4.1,-11.79,;-4.53,-13.27,;-6.02,-13.64,;-7.09,-12.53,;-6.66,-11.05,;-7.81,-10.03,;-7.67,-8.51,;-9.06,-7.88,;-10.09,-9.02,;-9.32,-10.35,;-9.94,-11.76,;-9.13,-13.07,;-9.86,-14.43,;-11.4,-14.47,;-12.21,-13.17,;-11.48,-11.81,;-6.34,-7.73,;-5.27,-8.35,;-6.35,-6.19,;-5.02,-5.42,;-5.02,-3.88,;-3.69,-3.1,;-2.35,-3.87,;-1.02,-3.09,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;.3,.77,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.3,-.77,;4.2,.03,;4.99,-1.28,;6.48,-.91,;7.42,-1.7,;6.59,.63,;5.16,1.21,;-2.35,-5.41,;-1.28,-6.02,;-3.68,-6.18,)| Show InChI InChI=1S/C34H25FN6O3S/c1-40-19-27(37-20-40)31-17-26-33(45-31)30(14-15-36-26)44-29-13-12-21(16-25(29)35)39-34(42)24-18-38-41(22-8-4-3-5-9-22)32(24)23-10-6-7-11-28(23)43-2/h3-20H,1-2H3,(H,39,42) | PDB
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| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Macrophage-stimulating protein receptor
(Homo sapiens (Human)) | BDBM50114393
(CHEMBL3609806)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(cc3F)N3CC(=O)Nc4c(cnn4-c4ccccc4)C3=O)c2s1 Show InChI InChI=1S/C29H20FN7O3S/c1-35-14-22(32-16-35)25-12-21-27(41-25)24(9-10-31-21)40-23-8-7-18(11-20(23)30)36-15-26(38)34-28-19(29(36)39)13-33-37(28)17-5-3-2-4-6-17/h2-14,16H,15H2,1H3,(H,34,38) | PDB
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| n/a | n/a | 361 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human RON |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
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