| Reaction Details |
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 | Report a problem with these data |
| Target | S-methyl-5'-thioadenosine phosphorylase |
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| Ligand | BDBM22113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1511510 (CHEMBL3606935) |
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| Ki | 0.530000±n/a nM |
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| Citation |  Evans, GB; Cameron, SA; Luxenburger, A; Guan, R; Suarez, J; Thomas, K; Schramm, VL; Tyler, PC Tight binding enantiomers of pre-clinical drug candidates. Bioorg Med Chem23:5326-33 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-methyl-5'-thioadenosine phosphorylase |
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| Name: | S-methyl-5'-thioadenosine phosphorylase |
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| Synonyms: | 5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 31239.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
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| BDBM22113 |
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| n/a |
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| Name | BDBM22113 |
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| Synonyms: | (3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | (3R,4S)-1-[(9-Deazaadenin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine, 7 | DADMe-ImmA-Me | MT-DADMe-ImmA |
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| Type | n/a |
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| Emp. Form. | C13H19N5OS |
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| Mol. Mass. | 293.388 |
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| SMILES | CSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r| |
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| Structure | 
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