| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-amylase 1A |
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| Ligand | BDBM50120828 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1516310 (CHEMBL3618750) |
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| IC50 | 680000±n/a nM |
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| Citation |  Al-Asri, J; Fazekas, E; Lehoczki, G; Perdih, A; Görick, C; Melzig, MF; Gyémánt, G; Wolber, G; Mortier, J From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors. Bioorg Med Chem23:6725-32 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-amylase 1A |
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| Name: | Alpha-amylase 1A |
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| Synonyms: | 1,4-alpha-D-glucan glucanohydrolase 1 | AMY1 | AMY1A | AMY1A_HUMAN | Alpha-amylase | Salivary alpha-amylase |
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| Type: | Glycosidase |
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| Mol. Mass.: | 57770.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Sigma Chemical Co. |
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| Residue: | 511 |
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| Sequence: | MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGL
LDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLNSNWFPEG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RYFENGKDVNDWVGPPNDNGVTKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
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| BDBM50120828 |
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| n/a |
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| Name | BDBM50120828 |
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| Synonyms: | CHEMBL590969 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N2O4S |
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| Mol. Mass. | 328.342 |
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| SMILES | OC(=O)c1ccc(Nc2nc(cs2)-c2ccc(O)cc2O)cc1 |
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| Structure | 
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