| Reaction Details |
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 | Report a problem with these data |
| Target | Pancreatic alpha-amylase |
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| Ligand | BDBM50120856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1516321 (CHEMBL3618913) |
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| Ki | 6100±n/a nM |
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| Citation |  Al-Asri, J; Fazekas, E; Lehoczki, G; Perdih, A; Görick, C; Melzig, MF; Gyémánt, G; Wolber, G; Mortier, J From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors. Bioorg Med Chem23:6725-32 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pancreatic alpha-amylase |
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| Name: | Pancreatic alpha-amylase |
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| Synonyms: | 1,4-alpha-D-glucan glucanohydrolase | AMY2A | AMYP_HUMAN | PA | Pancreatic α-amylase (HPA) | Pancreatic alpha-amylase | Pancreatic alpha-amylase (HPA) |
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| Type: | Protein |
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| Mol. Mass.: | 57709.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 511 |
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| Sequence: | MKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGL
LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
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| BDBM50120856 |
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| n/a |
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| Name | BDBM50120856 |
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| Synonyms: | CHEMBL3618495 |
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| Type | Small organic molecule |
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| Emp. Form. | C55H68O32 |
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| Mol. Mass. | 1241.1092 |
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| SMILES | COc1cc(\C=C\C(=O)OC[C@H]2O[C@@H](O[C@@H]3[C@H](O)[C@@H](O)[C@H](C)O[C@H]3OC3=C(Cc4cc(O)cc(O)c4C3=O)c3cc(O)c(O[C@@H]4OC[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)c(O)c3)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@@H]2O)ccc1O |r,t:26| |
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| Structure | 
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