| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-beta |
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| Ligand | BDBM50121988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1517043 (CHEMBL3619502) |
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| EC50 | 4100±n/a nM |
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| Citation |  Fauber, BP; Gobbi, A; Savy, P; Burton, B; Deng, Y; Everett, C; La, H; Johnson, AR; Lockey, P; Norman, M; Wong, H Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists. Bioorg Med Chem Lett25:4109-13 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-beta |
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| Name: | Nuclear receptor ROR-beta |
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| Synonyms: | NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53227.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107979 |
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| Residue: | 470 |
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| Sequence: | MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM50121988 |
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| n/a |
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| Name | BDBM50121988 |
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| Synonyms: | CHEMBL3617309 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18ClFN2O3S |
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| Mol. Mass. | 444.906 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(NC(=O)c3ccccc3Cl)cc12 |
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| Structure | 
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