| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 11 |
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| Ligand | BDBM50322422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522031 (CHEMBL3627138) |
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| IC50 | >10000±n/a nM |
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| Citation |  Yao, Y; Tu, Z; Liao, C; Wang, Z; Li, S; Yao, H; Li, Z; Jiang, S Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. J Med Chem58:7672-80 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 11 |
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| Name: | Histone deacetylase 11 |
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| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 39187.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96DB2 |
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| Residue: | 347 |
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| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
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| BDBM50322422 |
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| n/a |
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| Name | BDBM50322422 |
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| Synonyms: | CHEMBL1173445 | Largazole |
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| Type | Small organic molecule |
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| Emp. Form. | C29H42N4O5S3 |
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| Mol. Mass. | 622.863 |
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| SMILES | CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)C2=N[C@@](C)(CS2)C(=O)N[C@@H](C(C)C)C(=O)O1 |r,t:26| |
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| Structure | 
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