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TargetCoagulation factor IX
LigandBDBM50125979
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1522950
Ki 1.000000±n/a nM
Citation Zhang TAndre PBateman TJChen YHDesai KEllsworth KGeissler WMGuo LHruza AJian TMeng DParker DLQian XReichert PSherer ECShu MSmith CJSonatore LMTschirret-Guth RNolting AFOrr RCampeau LCAraki KNishimura TSakurada IWood HB Development of a novel class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett 25:4945-9 (2015) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor IX
Name:Coagulation factor IX
Synonyms:Christmas factor | Coagulation factor IX precursor | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:Enzyme
Mol. Mass.:51768.83
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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  Blast E-value cutoff:
BDBM50125979
n/a
NameBDBM50125979
Synonyms:CHEMBL3627899
TypeSmall organic molecule
Emp. Form.C27H20Cl2F2N6O2
Mol. Mass.569.39
SMILESCc1ncn(n1)-c1cc(Cl)c(C(=O)NC[C@@H](c2cccc(F)c2)c2nc3c(F)ccc(C)c3c(=O)[nH]2)c(Cl)c1 |r|
Structure
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