Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50126928 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1524005 (CHEMBL3630477) |
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Ki | 258±n/a nM |
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Citation | Meng, D; Andre, P; Bateman, TJ; Berger, R; Chen, YH; Desai, K; Dewnani, S; Ellsworth, K; Feng, D; Geissler, WM; Guo, L; Hruza, A; Jian, T; Li, H; Metzger, J; Parker, DL; Reichert, P; Sherer, EC; Smith, CJ; Sonatore, LM; Tschirret-Guth, R; Wu, J; Xu, J; Zhang, T; Campeau, LC; Orr, R; Poirier, M; McCabe-Dunn, J; Araki, K; Nishimura, T; Sakurada, I; Hirabayashi, T; Wood, HB Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett25:5437-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50126928 |
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n/a |
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Name | BDBM50126928 |
Synonyms: | CHEMBL3628837 |
Type | Small organic molecule |
Emp. Form. | C24H24Cl2N6O2 |
Mol. Mass. | 499.392 |
SMILES | CC(O)[C@]1(CCc2nn3cc(C)ccc3c2C1)NC(=O)c1c(Cl)cc(cc1Cl)-n1cnc(C)n1 |r| |
Structure |
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