| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxyacylglutathione hydrolase, mitochondrial |
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| Ligand | BDBM50126960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1524149 (CHEMBL3631234) |
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| Ki | 81±n/a nM |
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| Citation |  Sang, Y; Shi, Q; Mo, M; Ni, C; Li, Z; Liu, B; Deng, Q; Creighton, DJ; Zheng, ZB Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorg Med Chem Lett25:4724-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxyacylglutathione hydrolase, mitochondrial |
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| Name: | Hydroxyacylglutathione hydrolase, mitochondrial |
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| Synonyms: | GLO2_BOVIN | Glx II | Glyoxalase II | HAGH | Hydroxyacylglutathione hydrolase, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34097.41 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_109913 |
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| Residue: | 308 |
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| Sequence: | MVLGRGLLGRWSVAELGAVCARLGLGPALLGSLHHLGLRKSLTVDQGTMKVELLPALTDN
YMYLLIDEDTKEAAIVDPVQPQKVVETARKHGVKLTTVLTTHHHWDHAGGNEKLVKLEPG
LKVYGGDDRIGALTHKVTHLSTLQVGSLHVKCLSTPCHTSGHICYFVTKPNSPEPPAVFT
GDTLFVAGCGKFYEGTADEMYKALLEVLGRLPADTRVYCGHEYTINNLKFARHVEPDNTA
VREKLAWAKEKYSIGEPTVPSTIAEEFTYNPFMRVREKTVQQHAGETEPVATMRAIRKEK
DQFKMPRD
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| BDBM50126960 |
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| n/a |
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| Name | BDBM50126960 |
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| Synonyms: | CHEMBL3629116 |
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| Type | Small organic molecule |
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| Emp. Form. | C58H78Br2N14O26S2 |
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| Mol. Mass. | 1611.256 |
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| SMILES | ON(C(=O)SCC(NC(=O)CCC(NCCC(=O)OCCNC(=O)CCNC(=O)CC(=O)NCCNC(=O)CC(=O)NCCC(=O)NCCOC(=O)CCNC(CCC(=O)NC(CSC(=O)N(O)c1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O)C(O)=O)C(=O)NCC(O)=O)c1ccc(Br)cc1 |
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| Structure | 
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