Ki Summary

Reaction Details

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Target

Receptor-interacting serine/threonine-protein kinase 2

Ligand

BDBM50139604

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1522562 (CHEMBL3631915)

IC50

63±n/a nM

Citation

Charnley, AK; Convery, MA; Lakdawala Shah, A; Jones, E; Hardwicke, P; Bridges, A; Ouellette, M; Totoritis, R; Schwartz, B; King, BW; Wisnoski, DD; Kang, J; Eidam, PM; Votta, BJ; Gough, PJ; Marquis, RW; Bertin, J; Casillas, L Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity. Bioorg Med Chem23:7000-6 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Receptor-interacting serine/threonine-protein kinase 2

Name:

Receptor-interacting serine/threonine-protein kinase 2

Synonyms:

Type:

Protein

Mol. Mass.:

61201.30

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

540

Sequence:

MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM

BDBM50139604

n/a

Name

BDBM50139604

Synonyms:

1-(5-tert-Butyl-isoxazol-3-yl)-3-[4-(pyridin-4-yloxy)-phenyl]-urea | 1-(5-tert-butylisoxazol-3-yl)-3-(4-(pyridin-4-yloxy)phenyl)urea | CHEMBL166031

Type

Small organic molecule

Emp. Form.

C19H20N4O3

Mol. Mass.

352.3871

SMILES

CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)no1

Structure