| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
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| Ligand | BDBM50134186 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1537821 (CHEMBL3737792) |
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| IC50 | 22000±n/a nM |
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| Citation |  Chen, P; Feng, D; Qian, X; Apgar, J; Wilkening, R; Kuethe, JT; Gao, YD; Scapin, G; Cox, J; Doss, G; Eiermann, G; He, H; Li, X; Lyons, KA; Metzger, J; Petrov, A; Wu, JK; Xu, S; Weber, AE; Yan, Y; Roy, RS; Biftu, T Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin. Bioorg Med Chem Lett25:5767-71 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase FAP |
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| Name: | Prolyl endopeptidase FAP |
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| Synonyms: | APCE | Antiplasmin-cleaving enzyme FAP, soluble form | Dipeptidyl peptidase FAP | FAP | FAPalpha | Fibroblast activation protein alpha | Gelatine degradation protease FAP | Integral membrane serine protease | Post-proline cleaving enzyme | Prolyl endopeptidase FAP | SEPR_BOVIN | SIMP | Seprase | Serine integral membrane protease | Surface-expressed protease | Z-Pro-prolinal insensitive peptidase | ZIP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87742.67 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_116681 |
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| Residue: | 760 |
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| Sequence: | MKTWLKIVFGVATSAVLALLVMCIVLRPSRVHNSEESTTRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSTDNNVVFYNIETGESYTILSNTTMKSVNASNYGLSPDRQFAYLESDYSK
LWRYSYTATYHIYDLTNGEFIRRNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPEDPP
FQITYNGKENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTEIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDATYPEHIGPREVPVPAMIASSDYYFSWLTWVT
DDRICLQWLKRIQNVSVLSTCDFREDWQTWNCPKTQEHIEESRTGWAGGFFVSTPVFSHD
TISYYKIFSDKDGYKHIHYIRDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEGYPG
RRNIYRISIGSHSPSKKCITCHLRKKRCQYYTASFSDYAKYYALVCYGPGLPISTLHDGR
TDQEIKILEDNKELENALKNIQLPKEEIKKLKVDDITLWYKMILPPQFDKSKKYPLLIQV
YGGPCSQSVRSIFAVSWISYLASKEGIVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASIY
TERFMGLPTKDDNLKHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTKHLYTHMTHFLKQCFSLSD
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| BDBM50134186 |
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| n/a |
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| Name | BDBM50134186 |
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| Synonyms: | CHEMBL3734964 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23F2N5O2 |
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| Mol. Mass. | 403.4257 |
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| SMILES | N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2[nH]nc(NC(=O)C3CC3)c2C1 |r| |
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| Structure | 
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