Reaction Details |
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Target | Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
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Ligand | BDBM50380728 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1544143 (CHEMBL3750901) |
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IC50 | 17±n/a nM |
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Citation | Desai, AJ; Lam, PC; Orry, A; Abagyan, R; Christopoulos, A; Sexton, PM; Miller, LJ Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex. J Med Chem58:9562-77 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
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Name: | Cholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor |
Synonyms: | Cholecystokinin receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1544143 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gastrin/cholecystokinin type B receptor |
Synonyms: | Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48980.43 |
Organism: | RAT |
Description: | Cholecystokinin A CCKBR RAT::P30553 |
Residue: | 452 |
Sequence: | MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
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Component 2 |
Name: | Cholecystokinin receptor type A |
Synonyms: | CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49676.37 |
Organism: | RAT |
Description: | Cholecystokinin central 0 RAT::P30551 |
Residue: | 444 |
Sequence: | MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP
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BDBM50380728 |
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n/a |
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Name | BDBM50380728 |
Synonyms: | CHEMBL2017835 |
Type | Small organic molecule |
Emp. Form. | C40H39N7O2 |
Mol. Mass. | 649.7834 |
SMILES | Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r| |
Structure |
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