| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50134712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1543862 (CHEMBL3749752) |
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| IC50 | 144000±n/a nM |
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| Citation |  Tan, X; Song, YH; Park, C; Lee, KW; Kim, JY; Kim, DW; Kim, KD; Lee, KW; Curtis-Long, MJ; Park, KH Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking. Bioorg Med Chem24:153-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50134712 |
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| n/a |
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| Name | BDBM50134712 |
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| Synonyms: | CHEMBL3746218 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28O7 |
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| Mol. Mass. | 440.4856 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])ccc(c1-[#8])C1([#8])[#6]-[#8]-c2cc(-[#8])cc(-[#8])c2-[#6]1=O |
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| Structure | 
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