| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vitamin D3 receptor |
|---|
| Ligand | BDBM50135031 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1544902 (CHEMBL3751598) |
|---|
| IC50 | 13±n/a nM |
|---|
| Citation |  Watarai, Y; Ishizawa, M; Ikura, T; Zacconi, FC; Uno, S; Ito, N; Mouriņo, A; Tokiwa, H; Makishima, M; Yamada, S Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds. J Med Chem58:9510-21 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vitamin D3 receptor |
|---|
| Name: | Vitamin D3 receptor |
|---|
| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 48288.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11473 |
|---|
| Residue: | 427 |
|---|
| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
|
|
|
|---|
| BDBM50135031 |
|---|
| n/a |
|---|
| Name | BDBM50135031 |
|---|
| Synonyms: | CHEMBL3747243 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H44O3 |
|---|
| Mol. Mass. | 500.7114 |
|---|
| SMILES | [H][C@@]12[#6]-[#6]-[#6@H](C#CC#C[#6@H](-[#8])C34[#6]-[#6]-5-[#6]-[#6](-[#6]-[#6](-[#6]-5)-[#6]3)-[#6]4)[C@@]1([#6])[#6]-[#6]-[#6]\[#6]2=[#6]/[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r,TLB:18:13:20:17.19.16,18:17:20:12.13.14,THB:16:15:12:18.17.19,16:17:12:20.14.15| |
|---|
| Structure | 
|
|---|
Search and Browse
