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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50136453
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1548095
EC50 550±n/a nM
Citation Horan JCKuzmich DLiu PDiSalvo DLord JMao CHopkins TDYu HHarcken CBetageri RHill-Drzewi MPatenaude LPatel MFletcher KTerenzzio DLinehan BXia HPatel MStudwell DMiller CHickey ELevin JISmith DKemper RAModis LKBannen LCChan DSMac MBNg SWang YXu WLemieux RM Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists. Bioorg Med Chem Lett 26:466-71 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50136453
n/a
NameBDBM50136453
Synonyms:CHEMBL3752624
TypeSmall organic molecule
Emp. Form.C22H23ClFN5O3S
Mol. Mass.491.966
SMILESCC(C)Nc1cc(cc(C)n1)-c1nnc(s1)-c1cc(F)c(OC[C@H]2CNC(=O)CO2)cc1Cl |r|
Structure
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