Reaction Details |
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Target | Prostaglandin E2 receptor EP4 subtype |
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Ligand | BDBM50140262 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1548137 (CHEMBL3754939) |
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IC50 | 0.730000±n/a nM |
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Citation | Blanco, MJ; Vetman, T; Chandrasekhar, S; Fisher, MJ; Harvey, A; Chambers, M; Lin, C; Mudra, D; Oskins, J; Wang, XS; Yu, XP; Warshawsky, AM Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile. Bioorg Med Chem Lett26:931-5 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E2 receptor EP4 subtype |
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Name: | Prostaglandin E2 receptor EP4 subtype |
Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
Type: | Enzyme |
Mol. Mass.: | 53134.53 |
Organism: | Homo sapiens (Human) |
Description: | P35408 |
Residue: | 488 |
Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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BDBM50140262 |
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n/a |
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Name | BDBM50140262 |
Synonyms: | CHEMBL3753567 |
Type | Small organic molecule |
Emp. Form. | C23H20FNO4 |
Mol. Mass. | 393.4076 |
SMILES | Cc1cc(cc(C)c1NC(=O)c1cc(ccc1F)-c1cccc(CO)c1)C(O)=O |
Structure |
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