| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50140689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1548641 (CHEMBL3757641) |
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| IC50 | 2000±n/a nM |
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| Citation |  Di Micco, S; Spatafora, C; Cardullo, N; Riccio, R; Fischer, K; Pergola, C; Koeberle, A; Werz, O; Chalal, M; Vervandier-Fasseur, D; Tringali, C; Bifulco, G 2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors. Bioorg Med Chem24:820-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM50140689 |
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| n/a |
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| Name | BDBM50140689 |
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| Synonyms: | CHEMBL3752809 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H30O8 |
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| Mol. Mass. | 566.5972 |
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| SMILES | Oc1cc(\C=C\C(=O)OCCc2ccccc2)cc2[C@H]([C@@H](Oc12)c1ccc(O)c(O)c1)C(=O)OCCc1ccccc1 |r| |
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| Structure | 
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