Ki Summary

Reaction Details

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Target

Prostaglandin E synthase

Ligand

BDBM50393042

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1552422

IC50

0.241000±n/a nM

Citation

Schiffler MA; Antonysamy S; Bhattachar SN; Campanale KM; Chandrasekhar S; Condon B; Desai PV; Fisher MJ; Groshong C; Harvey A; Hickey MJ; Hughes NE; Jones SA; Kim EJ; Kuklish SL; Luz JG; Norman BH; Rathmell RE; Rizzo JR; Seng TW; Thibodeaux SJ; Woods TA; York JS; Yu XP Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J Med Chem 59:194-205 (2016) [PubMed]

More Info.:

Get all data from this article, Assay Method

Prostaglandin E synthase

Name:

Prostaglandin E synthase

Synonyms:

Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E2 synthase-1 ( mPGES-1)

Type:

Protein

Mol. Mass.:

17112.22

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

152

Sequence:

MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL

BDBM50393042

n/a

Name

BDBM50393042

Synonyms:

CHEMBL2152712

Type

Small organic molecule

Emp. Form.

C16H19ClN4O2

Mol. Mass.

334.801

SMILES

CC(C)(C)C(=O)NCc1ccc(Cl)c(c1)C(=O)Nc1ncc[nH]1

Structure