| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 13 member 2 |
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| Ligand | BDBM50149244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1557734 (CHEMBL3773093) |
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| IC50 | 13200±n/a nM |
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| Citation |  Huard, K; Gosset, JR; Montgomery, JI; Gilbert, A; Hayward, MM; Magee, TV; Cabral, S; Uccello, DP; Bahnck, K; Brown, J; Purkal, J; Gorgoglione, M; Lanba, A; Futatsugi, K; Herr, M; Genung, NE; Aspnes, G; Polivkova, J; Garcia-Irizarry, CN; Li, Q; Canterbury, D; Niosi, M; Vera, NB; Li, Z; Khunte, B; Siderewicz, J; Rolph, T; Erion, DM Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem59:1165-75 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 13 member 2 |
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| Name: | Solute carrier family 13 member 2 |
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| Synonyms: | NADC1 | NADC1 | Na(+)/dicarboxylate cotransporter 1 | NaDC-1 | Renal sodium/dicarboxylate cotransporter | S13A2_HUMAN | SDCT1 | SLC13A2 | Solute carrier family 13 member 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64412.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_114812 |
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| Residue: | 592 |
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| Sequence: | MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTA
LFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVR
PAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQ
EPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGT
APNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGI
GEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFP
NAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWN
IVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATT
TIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAG
FLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP
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| BDBM50149244 |
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| n/a |
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| Name | BDBM50149244 |
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| Synonyms: | CHEMBL3771118 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17NO6 |
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| Mol. Mass. | 283.2772 |
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| SMILES | COc1ncc(C)cc1CC[C@@](O)(CC(O)=O)C(O)=O |r| |
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| Structure | 
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