Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 8 |
---|
Ligand | BDBM50154943 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1559661 (CHEMBL3779075) |
---|
IC50 | 49±n/a nM |
---|
Citation | Schiemann, K; Mallinger, A; Wienke, D; Esdar, C; Poeschke, O; Busch, M; Rohdich, F; Eccles, SA; Schneider, R; Raynaud, FI; Czodrowski, P; Musil, D; Schwarz, D; Urbahns, K; Blagg, J Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. Bioorg Med Chem Lett26:1443-51 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclin-dependent kinase 8 |
---|
Name: | Cyclin-dependent kinase 8 |
Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 53300.21 |
Organism: | Homo sapiens (Human) |
Description: | P49336 |
Residue: | 464 |
Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
|
|
|
BDBM50154943 |
---|
n/a |
---|
Name | BDBM50154943 |
Synonyms: | CHEMBL3775576 |
Type | Small organic molecule |
Emp. Form. | C18H17N5O |
Mol. Mass. | 319.3605 |
SMILES | CNC(=O)c1ccc2[nH]nc(Cc3ccc4n(C)ncc4c3)c2c1 |
Structure |
|