| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Branched-chain-amino-acid aminotransferase, mitochondrial |
|---|
| Ligand | BDBM50162494 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1570254 (CHEMBL3795165) |
|---|
| IC50 | <1258925±n/a nM |
|---|
| Citation |  Borthwick, JA; Ancellin, N; Bertrand, SM; Bingham, RP; Carter, PS; Chung, CW; Churcher, I; Dodic, N; Fournier, C; Francis, PL; Hobbs, A; Jamieson, C; Pickett, SD; Smith, SE; Somers, DO; Spitzfaden, C; Suckling, CJ; Young, RJ Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening. J Med Chem59:2452-67 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Branched-chain-amino-acid aminotransferase, mitochondrial |
|---|
| Name: | Branched-chain-amino-acid aminotransferase, mitochondrial |
|---|
| Synonyms: | BCAT(m) | BCAT2 | BCAT2_HUMAN | BCATM | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44297.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109874 |
|---|
| Residue: | 392 |
|---|
| Sequence: | MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
|
|
|
|---|
| BDBM50162494 |
|---|
| n/a |
|---|
| Name | BDBM50162494 |
|---|
| Synonyms: | CHEMBL3792871 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H6N2OS |
|---|
| Mol. Mass. | 166.2 |
|---|
| SMILES | OCc1ccc2nsnc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
